Analysis of Platelet Membrane Glycoproteins in Myeloproliferative Disorders
نویسندگان
چکیده
منابع مشابه
974 Platelet Membrane Glycoproteins
Glycoproteins I Ib / I I Ia form a Ca2+-dependent complex that functions as the fibrinogen receptor on human platelets (1). Several reports have indicated that this fibrinogen receptor is also expressed on the surface of human monocytes (2-4). Of three monoclonal antibodies directed against platelet I Ib/ I I Ia , two were reported to give a positive reaction with monocytes as well (4). Other i...
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The function of blood platelets to prevent blood loss at injured sites in the vasculature depends largely on their capacity to adhere, aggregate, promote coagulation and secrete factors that induce vasoconstriction and recruit inflammatory cells. Produced in large numbers from megakaryocytes, platelets enter the circulation for 7–10 days primed to fulfill their hemostatic function. By 1970, tho...
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متن کاملIncreased platelet-fibrinogen affinity in patients with myeloproliferative disorders.
Patients with myeloproliferative disorders (MPD) are known to have some abnormalities of platelet glycoproteins (Gp). Quantitative changes of the Gp Ib, IIb-IIIa, and/or their glucidic content have been reported. Since the Gp IIb-IIIa complex plays a major role in fibrinogen binding by activated platelets, we measured the platelet fibrinogen affinity in nine patients with polycythemia vera (PV)...
متن کاملPlatelet function and thromboxane synthesis in myeloproliferative disorders.
We have read with interest the paper of Landolfi et al,’ “Increased Thromboxane Biosynthesis in Patients With Polycythemia Vera: Evidence for Aspirin-Suppressible Platelet Activation In Vivo.” In a recent publication’ on 1 1 patients with chronic myeloproliferative disorders (CMPD), 7 with essential thrombocytosis and 4 with polycytnemia vera, we have reached a similar conclusion (with respect ...
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ژورنال
عنوان ژورنال: Blood & Vessel
سال: 1979
ISSN: 0386-9717,1884-2372
DOI: 10.2491/jjsth1970.10.545